Article
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2015
Pelleau Stéphane, Moss Eli L, Dhingra Satish K, Volney Béatrice, Casteras Jessica, Gabryszewski Stanislaw J, Volkman Sarah K, Wirth Dyann F, Legrand Eric, Fidock David A, Neafsey Daniel E, Musset Lise
Abstract excerpt
In regions with high malaria endemicity, the withdrawal of chloroquine (CQ) as first-line treatment of Plasmodium falciparum infections has typically led to the restoration of CQ susceptibility through the reexpansion of the wild-type (WT) allele K76 of the chloroquine resistance transporter gene (pfcrt) at the expense of less fit mutant alleles carrying the CQ resistance (CQR) marker K76T. In low-transmission...
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