Article
Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.
PLoS pathogens - 1 Feb 2022
Small-Saunders Jennifer L, Hagenah Laura M, Wicht Kathryn J, Dhingra Satish K, Deni Ioanna, Kim Jonathan, Vendome Jeremie, Gil-Iturbe Eva, Roepe Paul D, Mehta Monica, Mancia Filippo, Quick Matthias, Eppstein Margaret J, Fidock David A
Abstract excerpt
Multidrug-resistant Plasmodium falciparum parasites have emerged in Cambodia and neighboring countries in Southeast Asia, compromising the efficacy of first-line antimalarial combinations. Dihydroartemisinin + piperaquine (PPQ) treatment failure rates have risen to as high as 50% in some areas in this region. For PPQ, resistance is driven primarily by a series of mutant alleles of the P. falciparum chloroquine...
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