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Article

Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.

PLoS pathogens - 13 May 2010

Valderramos Stephanie G, Valderramos Juan-Carlos, Musset Lise, Purcell Lisa A, Mercereau-Puijalon Odile, Legrand Eric, Fidock David A

Abstract excerpt

Mutant forms of the Plasmodium falciparum transporter PfCRT constitute the key determinant of parasite resistance to chloroquine (CQ), the former first-line antimalarial, and are ubiquitous to infections that fail CQ treatment. However, treatment can often be successful in individuals harboring mutant pfcrt alleles, raising questions about the role of host immunity or pharmacokinetics vs. the parasite genetic...

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Identifiers

PMID: 20485514
DOI: 10.1371/journal.ppat.1000887
PMCID: PMC2869323

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Source receipt: pubmed, retrieved 7 Sept 2026.

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