Article
The return of chloroquine-sensitive Plasmodium falciparum parasites in Jazan region, southwestern Saudi Arabia over a decade after the adoption of artemisinin-based combination therapy: analysis of genetic mutations in the pfcrt gene.
Parasitology research - 1 Nov 2021
Madkhali Aymen M, Abdulhaq Ahmed A, Atroosh Wahib M, Ghzwani Ahmad Hassn, Zain Khalid Ammash, Ghailan Khalid Y, Hamali Hassan A, Mobarki Abdullah A, Eisa Zaki M, Lau Yee-Ling, Al-Mekhlafi Hesham M
Abstract excerpt
This study investigated the polymorphism in the P. falciparum chloroquine resistance transporter (pfcrt) gene 11 years after chloroquine (CQ) cessation in Jazan region, southwestern Saudi Arabia. Two hundred and thirty-five P. falciparum isolates were amplified to detect mutations in the pfcrt gene. The pfcrt 76 T molecular marker for CQ resistance was detected in 66.4% (156/235) of the isolates, while the K76...
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