Article
Return of chloroquine sensitivity to Africa? Surveillance of African Plasmodium falciparum chloroquine resistance through malaria imported to China.
Parasites & vectors - 26 Jul 2017
Lu Feng, Zhang Meihua, Culleton Richard L, Xu Sui, Tang Jianxia, Zhou Huayun, Zhu Guoding, Gu Yaping, Zhang Chao, Liu Yaobao, Wang Weiming, Cao Yuanyuan, Li Julin, He Xinlong, Cao Jun, Gao Qi
Abstract excerpt
BACKGROUND: Chloroquine (CQ) was the cornerstone of anti-malarial treatment in Africa for almost 50 years, but has been widely withdrawn due to the emergence and spread of resistance. Recent reports have suggested that CQ-susceptibility may return following the cessation of CQ usage. Here, we monitor CQ sensitivity and determine the prevalence of genetic polymorphisms in the CQ resistance transporter gene (pfcrt)...
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