Article
The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9.
Pharmacological reviews - 1 Jan 2017
Seidah Nabil G, Abifadel Marianne, Prost Stefan, Boileau Catherine, Prat Annik
Abstract excerpt
The secretory proprotein convertase (PC) family comprises nine members, as follows: PC1/3, PC2, furin, PC4, PC5/6, paired basic amino acid cleaving enzyme 4, PC7, subtilisin kexin isozyme 1/site 1 protease (SKI-1/S1P), and PC subtilisin/kexin type 9 (PCSK9). The first seven PCs cleave their substrates at single/paired basic residues and exhibit specific and often essential functions during development and/or in...
Topics
- Animals
- Anticholesteremic Agents
- Biomarkers
- Cardiovascular Diseases
- Cholesterol
- Female
- Haplotypes
- Humans
- Hypercholesterolemia
- Lipoprotein(a)
- Male
- Mutation
- PCSK9 Inhibitors
- Phylogeny
- Proprotein Convertase 9
- Proteolysis
- Receptors, LDL
- Serine Proteinase Inhibitors