Article
Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits.
American journal of human genetics - 7 Apr 2022
Highland Heather M, Wojcik Genevieve L, Graff Mariaelisa, Nishimura Katherine K, Hodonsky Chani J, Baldassari Antoine R, Cote Alanna C, Cheng Iona, Gignoux Christopher R, Tao Ran, Li Yuqing, Boerwinkle Eric, Fornage Myriam, Haessler Jeffrey, Hindorff Lucia A, Hu Yao, Justice Anne E, Lin Bridget M, Lin Danyu, Stram Daniel O, Haiman Christopher A, Kooperberg Charles, Le Marchand Loic, Matise Tara C, Kenny Eimear E, Carlson Christopher S, Stahl Eli A, Avery Christy L, North Kari E, Ambite Jose Luis, Buyske Steven, Loos Ruth J, Peters Ulrike, Young Kristin L, Bien Stephanie A, Huckins Laura M
Abstract excerpt
One mechanism by which genetic factors influence complex traits and diseases is altering gene expression. Direct measurement of gene expression in relevant tissues is rarely tenable; however, genetically regulated gene expression (GReX) can be estimated using prediction models derived from large multi-omic datasets. These approaches have led to the discovery of many gene-trait associations, but whether models...
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