Article
Specific combinations of boundary element and Polycomb response element are required for the regulation of the Hox genes in Drosophila melanogaster.
Mechanisms of development - 1 Nov 2015
Singh Narendra Pratap, Mishra Rakesh Kumar
Abstract excerpt
In the bithorax complex of Drosophila melanogaster, the chromatin boundary elements (BE) demarcate cis-regulatory domains that regulate Hox genes along the anteroposterior body axis. These elements are closely associated with the Polycomb Response Elements (PREs) and restrict the ectopic activation of cis-regulatory domains during development. The relevance of such specific genomic arrangements of regulatory...
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