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Article

The Ubx Polycomb response element bypasses an unpaired Fab-8 insulator via cis transvection in Drosophila.

PloS one - 1 Jan 2018

Lu Danfeng, Li Zhuoran, Li Lingling, Yang Liping, Chen Guijun, Yang Deying, Zhang Yue, Singh Vikrant, Smith Sheryl, Xiao Yu, Wang Erlin, Ye Yunshuang, Zhang Wei, Zhou Lei, Rong Yikang, Zhou Jumin

Abstract excerpt

Chromatin insulators or boundary elements protect genes from regulatory activities from neighboring genes or chromatin domains. In the Drosophila Abdominal-B (Abd-B) locus, the deletion of such elements, such as Frontabdominal-7 (Fab-7) or Fab-8 led to dominant gain of function phenotypes, presumably due to the loss of chromatin barriers. Homologous chromosomes are paired in Drosophila, creating a number of...

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PMID: 29928011
DOI: 10.1371/journal.pone.0199353
PMCID: PMC6013190

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The Ubx Polycomb response element bypasses an unpaired Fab-8 insulator via cis transvection in Drosophila.PMID 29928011Read ↗

A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex.Semantic proximity Read ↗

The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.Semantic proximity Read ↗

Transvection in the Drosophila Abd-B domain: extensive upstream sequences are involved in anchoring distant cis-regulatory regions to the promoter.Semantic proximity Read ↗

In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element.Semantic proximity Read ↗

Enhancer blocking and transvection at the Drosophila apterous locus.Semantic proximity Read ↗

The iab-7 polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activity.Semantic proximity Read ↗

Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.Semantic proximity Read ↗

Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1.Semantic proximity Read ↗

The Mcp element from the bithorax complex contains an insulator that is capable of pairwise interactions and can facilitate enhancer-promoter communication.Semantic proximity Read ↗

RNAi components are required for nuclear clustering of Polycomb group response elements.Semantic proximity Read ↗

Specific combinations of boundary element and Polycomb response element are required for the regulation of the Hox genes in Drosophila melanogaster.Semantic proximity Read ↗

Replacement of a Drosophila Polycomb response element core, and in situ analysis of its DNA motifs.Semantic proximity Read ↗

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