Article
In situ dissection of a Polycomb response element in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jul 2007
Sipos László, Kozma Gabriella, Molnár Eniko, Bender Welcome
Abstract excerpt
Genes of the Polycomb group maintain long-term, segment-specific repression of the homeotic genes in Drosophila. DNA targets of Polycomb group proteins, called Polycomb response elements (PREs), have been defined by several assays, but they have not been dissected in their original chromosomal context. An enhanced method of gene conversion was developed to generate a series of small, targeted deletions...
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