In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element.

doi:10.1242/dev.124.9.1809

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Article

In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element.

Development (Cambridge, England) - 1 May 1997

Mihaly J, Hogga I, Gausz J, Gyurkovics H, Karch F

Abstract excerpt

Parasegmental (PS)-specific expression of the homeotic genes of the bithorax-complex (BX-C) appears to depend upon the subdivision of the complex into a series of functionally independent cis-regulatory domains. Fab-7 is a regulatory element that lies between iab-6 and iab-7 (the PS11- and PS12-s...

Topics

Abdomen
Animals
Animals, Genetically Modified
Chromatin
Crosses, Genetic
DNA Transposable Elements
Drosophila
Drosophila Proteins
Embryo, Nonmammalian
Enhancer Elements, Genetic
Gene Deletion
Genes, Insect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Insect Proteins

Mutation

Organ Specificity

Phenotype

Polycomb Repressive Complex 1

Source

Open in PubMed

Identifiers

PMID: 9165128
DOI: 10.1242/dev.124.9.1809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9165128-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element.PMID 9165128Read ↗

The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex.Semantic proximity Read ↗

The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.Semantic proximity Read ↗

A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex.Semantic proximity Read ↗

A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation.Semantic proximity Read ↗

The Fab-8 boundary defines the distal limit of the bithorax complex iab-7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain.Semantic proximity Read ↗

The iab-7 polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activity.Semantic proximity Read ↗

Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.Semantic proximity Read ↗

Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex.Semantic proximity Read ↗

Replacement of a Drosophila Polycomb response element core, and in situ analysis of its DNA motifs.Semantic proximity Read ↗

The Ubx Polycomb response element bypasses an unpaired Fab-8 insulator via cis transvection in Drosophila.Semantic proximity Read ↗

The Mcp element from the bithorax complex contains an insulator that is capable of pairwise interactions and can facilitate enhancer-promoter communication.Semantic proximity Read ↗

Transvection in the Drosophila Abd-B domain: extensive upstream sequences are involved in anchoring distant cis-regulatory regions to the promoter.Semantic proximity Read ↗

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