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Article

A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex.

Genetics - 1 Aug 1997

Hagstrom K, Muller M, Schedl P

Abstract excerpt

The homeotic genes of the Drosophila bithorax complex are controlled by a large cis-regulatory region that ensures their segmentally restricted pattern of expression. A deletion that removes the Frontabdominal-7 cis-regulatory region (Fab-7') dominantly transforms parasegment 11 into parasegment 12. Previous studies suggested that removal of a domain boundary element on the proximal side of Fab-7' is responsible...

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Identifiers

PMID: 9258680
DOI: 10.1093/genetics/146.4.1365
PMCID: PMC1208081

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A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex.PMID 9258680Read ↗

In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element.Semantic proximity Read ↗

A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation.Semantic proximity Read ↗

The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.Semantic proximity Read ↗

The Ubx Polycomb response element bypasses an unpaired Fab-8 insulator via cis transvection in Drosophila.Semantic proximity Read ↗

The Fab-8 boundary defines the distal limit of the bithorax complex iab-7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain.Semantic proximity Read ↗

Transvection in the Drosophila Abd-B domain: extensive upstream sequences are involved in anchoring distant cis-regulatory regions to the promoter.Semantic proximity Read ↗

The iab-7 polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activity.Semantic proximity Read ↗

The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex.Semantic proximity Read ↗

A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression.Semantic proximity Read ↗

Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products.Semantic proximity Read ↗

Replacement of a Drosophila Polycomb response element core, and in situ analysis of its DNA motifs.Semantic proximity Read ↗

dSAP18 and dHDAC1 contribute to the functional regulation of the Drosophila Fab-7 element.Semantic proximity Read ↗

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