Article
The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia.
Brain : a journal of neurology - 1 Feb 2006
Ohnishi Takashi, Hashimoto Ryota, Mori Takeyuki, Nemoto Kiyotaka, Moriguchi Yoshiya, Iida Hidehiro, Noguchi Hiroko, Nakabayashi Tetsuo, Hori Hiroaki, Ohmori Mayu, Tsukue Ryoutaro, Anami Kimitaka, Hirabayashi Naotugu, Harada Seiichi, Arima Kunimasa, Saitoh Osamu, Kunugi Hiroshi
Abstract excerpt
The catechol-O-methyl transferase (COMT) gene is considered to be a promising schizophrenia susceptibility gene. A common functional polymorphism (Val158Met) in the COMT gene affects dopamine regulation in the prefrontal cortex (PFC). Recent studies suggest that this polymorphism contributes to poor prefrontal functions, particularly working memory, in both normal individuals and patients with schizophrenia....
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