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Article

CoMEt: a statistical approach to identify combinations of mutually exclusive alterations in cancer.

Genome biology - 8 Aug 2015

Leiserson Mark D M, Wu Hsin-Ta, Vandin Fabio, Raphael Benjamin J

Abstract excerpt

Cancer is a heterogeneous disease with different combinations of genetic alterations driving its development in different individuals. We introduce CoMEt, an algorithm to identify combinations of alterations that exhibit a pattern of mutual exclusivity across individuals, often observed for alterations in the same pathway. CoMEt includes an exact statistical test for mutual exclusivity and techniques to perform...

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Identifiers

PMID: 26253137
DOI: 10.1186/s13059-015-0700-7
PMCID: PMC4531541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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