Article

A novel independence test for somatic alterations in cancer shows that biology drives mutual exclusivity but chance explains co-occurrence

2016-05-11

Abstract excerpt

Just like recurrent somatic alterations characterize cancer genes, mutually exclusive or co-occurring alterations across genes suggest functional interactions. Identifying such patterns in large cancer studies thus helps the discovery of unknown interactions. Many studies use Fisher’s exact test or simple permutation procedures for this purpose. These tests assume identical gene alteration probabilities across tum...

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Literature Corpus work: fc4540ad-5bc5-5136-9ec7-f93c74a06d0c
DOI: 10.1101/052803

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