Article
A Modeling Approach to Explain Mutually Exclusive and Co-Occurring Genetic Alterations in Bladder Tumorigenesis.
Cancer research - 1 Oct 2015
Remy Elisabeth, Rebouissou Sandra, Chaouiya Claudine, Zinovyev Andrei, Radvanyi François, Calzone Laurence
Abstract excerpt
Relationships between genetic alterations, such as co-occurrence or mutual exclusivity, are often observed in cancer, where their understanding may provide new insights into etiology and clinical management. In this study, we combined statistical analyses and computational modeling to explain patterns of genetic alterations seen in 178 patients with bladder tumors (either muscle-invasive or non-muscle-invasive)....
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