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Identifying actionable synthetically lethal cancer gene pairs using mutual exclusivity.

FEBS letters - 1 Aug 2024

Wooller Sarah K, Pearl Laurence H, Pearl Frances M G

Abstract excerpt

Mutually exclusive loss-of-function alterations in gene pairs are those that occur together less frequently than may be expected and may denote a synthetically lethal relationship (SSL) between the genes. SSLs can be exploited therapeutically to selectively kill cancer cells. Here, we analysed mutation, copy number variation, and methylation levels in samples from The Cancer Genome Atlas, using the hypergeometric...

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PMID: 38977941
DOI: 10.1002/1873-3468.14950

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