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Article

The bHLH Transcription Factor Hand Regulates the Expression of Genes Critical to Heart and Muscle Function in Drosophila melanogaster.

PloS one - 1 Jan 2015

Hallier Benjamin, Hoffmann Julia, Roeder Thomas, Tögel Markus, Meyer Heiko, Paululat Achim

Abstract excerpt

Hand proteins belong to the highly conserved family of basic Helix-Loop-Helix transcription factors and are critical to distinct developmental processes, including cardiogenesis and neurogenesis in vertebrates. In Drosophila melanogaster a single orthologous hand gene is expressed with absence of the respective protein causing semilethality during early larval instars. Surviving adult animals suffer from...

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Identifiers

PMID: 26252215
DOI: 10.1371/journal.pone.0134204
PMCID: PMC4529270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The bHLH Transcription Factor Hand Regulates the Expression of Genes Critical to Heart and Muscle Function in Drosophila melanogaster.PMID 26252215Read ↗

The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis.Semantic proximity Read ↗

Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis.Semantic proximity Read ↗

Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives.Semantic proximity Read ↗

The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.Semantic proximity Read ↗

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In-Silico analysis of HAND subclass bHLH transcription factor in CardiogenesisSemantic proximity Read ↗

A bHLH code for cardiac morphogenesis.Semantic proximity Read ↗

A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human heartsSemantic proximity Read ↗

Requirement of the LIM homeodomain transcription factor tailup for normal heart and hematopoietic organ formation in Drosophila melanogaster.Semantic proximity Read ↗

<i>fhl2b</i> expression ameliorates muscular dystrophySemantic proximity Read ↗

HAND proteins: molecular mediators of cardiac development and congenital heart disease.Semantic proximity Read ↗

Asymmetrically reduced expression of hand1 homeologs involving a single nucleotide substitution in a cis-regulatory element.Semantic proximity Read ↗

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