Article
The bHLH Transcription Factor Hand Regulates the Expression of Genes Critical to Heart and Muscle Function in Drosophila melanogaster.
PloS one - 1 Jan 2015
Hallier Benjamin, Hoffmann Julia, Roeder Thomas, Tögel Markus, Meyer Heiko, Paululat Achim
Abstract excerpt
Hand proteins belong to the highly conserved family of basic Helix-Loop-Helix transcription factors and are critical to distinct developmental processes, including cardiogenesis and neurogenesis in vertebrates. In Drosophila melanogaster a single orthologous hand gene is expressed with absence of the respective protein causing semilethality during early larval instars. Surviving adult animals suffer from...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Conserved Sequence
- Drosophila Proteins
- Drosophila melanogaster
- Evolution, Molecular
- Gene Expression Regulation, Developmental
- Heart
- Muscle Development
- Muscles
- Mutation
- Real-Time Polymerase Chain Reaction