Article
Asymmetrically reduced expression of hand1 homeologs involving a single nucleotide substitution in a cis-regulatory element.
Developmental biology - 15 May 2017
Ochi Haruki, Suzuki Nanoka, Kawaguchi Akane, Ogino Hajime
Abstract excerpt
During vertebrate evolution, whole genome duplications resulted in a number of duplicated genes, some of which eventually changed their expression patterns and/or levels via alteration of cis-regulatory sequences. However, the initial process involved in such cis-regulatory changes remains unclear. Therefore, we investigated this process by analyzing the duplicated hand1 genes of Xenopus laevis (hand1.L and...
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