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Article

The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis.

Developmental biology - 15 Nov 2007

Lo Patrick C H, Zaffran Stéphane, Sénatore Sébastien, Frasch Manfred

Abstract excerpt

The Hand proteins of the bHLH family of transcriptional factors play critical roles in vertebrate cardiogenesis. In Drosophila, the single orthologous Hand gene is expressed in the developing embryonic dorsal vessel (heart), lymph glands, circular visceral musculature, and a subset of CNS cells. We demonstrate that the absence of Hand activity causes semilethality during the early larval instars. The dorsal...

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Identifiers

PMID: 17904115
DOI: 10.1016/j.ydbio.2007.08.024
PMCID: PMC2128039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Drosophila Hand gene is required for remodeling of the developing adult heart and midgut during metamorphosis.PMID 17904115Read ↗

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Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis.Semantic proximity Read ↗

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The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.Semantic proximity Read ↗

Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives.Semantic proximity Read ↗

Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability.Semantic proximity Read ↗

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A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human heartsSemantic proximity Read ↗

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HAND transcription factors cooperatively specify the aorta and pulmonary trunk.Semantic proximity Read ↗

The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness.Semantic proximity Read ↗

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