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Article

Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice.

Reproductive toxicology (Elmsford, N.Y.) - 1 Dec 2015

Lim Jinhwan, Ortiz Laura, Nakamura Brooke N, Hoang Yvonne D, Banuelos Jesus, Flores Victoria N, Chan Jefferson Y, Luderer Ulrike

Abstract excerpt

Polycyclic aromatic hydrocarbons, like benzo[a]pyrene (BaP), are ubiquitous environmental pollutants and potent ovarian toxicants. The transcription factor NRF2 is an important regulator of the cellular response to electrophilic toxicants like BaP and to oxidative stress. NRF2 regulates transcription of genes involved in the detoxification of reactive metabolites of BaP and reactive oxygen species. We therefore...

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Identifiers

PMID: 26247513
DOI: 10.1016/j.reprotox.2015.07.080
PMCID: PMC4690751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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