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Article

Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice.

Molecular and cellular biology - 1 Feb 2006

Hu Xiaoming, Roberts Jenny R, Apopa Patrick L, Kan Yuet Wai, Ma Qiang

Abstract excerpt

Genetic and biochemical analyses have uncovered an essential role for nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating phase II xenobiotic metabolism and antioxidant response. Here we show that Nrf2 protects against the ovarian toxicity of 4-vinylcyclohexene diepoxide (VCD) in mice. Nrf2-/- female mice exposed to VCD exhibit an age-dependent decline in reproduction leading to secondary infertility...

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Source

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Identifiers

PMID: 16428448
DOI: 10.1128/MCB.26.3.940-954.2006
PMCID: PMC1347017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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