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Article

Nicotine exposure is associated with targeted impairments in primordial follicle phenotype in cultured neonatal mouse ovaries.

Ecotoxicology and environmental safety - 1 Dec 2024

Idrees Sara M, Waite Sarah L, Granados Aparici Sofia, Fenwick Mark A

Abstract excerpt

The ovarian reserve consists of a limited supply of primordial follicles (PFs), each containing an oocyte surrounded by a layer of granulosa cells (GCs). PFs are relatively quiescent and must remain viable for a long period, thereby making them susceptible to environmental and lifestyle influences. Given the widespread prevalence of e-cigarette use, this study aimed to investigate the effects of nicotine and its...

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PMID: 39546863
DOI: 10.1016/j.ecoenv.2024.117302

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