Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary

13 Feb 2019

Abstract excerpt

BACKGROUND: Age-associated infertility is a problem worldwide, and management of oxidative stress is known to be essential. Nuclear factor-E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)-antioxidant response element (ARE) signaling pathway works as an essential defense mechanism against oxidative stress, and an oral drug Dimethylfumarate (DMF) is known to activate the pathway. METHODS: We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Stress and Disease
Share to Genomics, phytochemicals, and oxidative stress
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30760288
DOI: 10.1186/s12958-019-0466-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovaryPMID 30760288Read ↗

Role of nuclear factor erythroid 2-related factor 2 (Nrf2) in female and male fertilitySemantic proximity Read ↗

The Antioxidant Auraptene Improves Aged Oocyte Quality and Embryo Development in MiceSemantic proximity Read ↗

Cell-Free Fat Extract Improves Ovarian Function and Fertility in Mice With Advanced AgeSemantic proximity Read ↗

KEAP1 – NRF2 system regulates age‐related spermatogenesis dysfunctionSemantic proximity Read ↗

Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytesSemantic proximity Read ↗

Redox Regulation in Age-Related Cataracts: Roles for Glutathione, Vitamin C, and the NRF2 Signaling PathwaySemantic proximity Read ↗

Antioxidant Intervention Attenuates Aging-Related Changes in the Murine Ovary and OocyteSemantic proximity Read ↗

Oral antioxidants counteract the negative effects of female aging on oocyte quantity and quality in the mouseSemantic proximity Read ↗

Elamipretide reverses female fertility decline during reproductive aging via regulating VEGF in oocytesSemantic proximity Read ↗

Fisetin Delays Postovulatory Oocyte Aging by Regulating Oxidative Stress and Mitochondrial Function through Sirt1 PathwaySemantic proximity Read ↗

Cyclophosphamide‐Induced Infertility and the Impact of AntioxidantsSemantic proximity Read ↗

Regulatory factors of Nrf2 in age-related macular degeneration pathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.