Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytes

28 Mar 2019

Abstract excerpt

It is well established that DNA-damaging chemotherapies can cause infertility and ovarian endocrine failure by depleting the ovarian reserve of primordial follicles. Currently, no effective pharmacological therapies exist for the preservation of long-term fertility and ovarian function in female cancer patients, due to a limited understanding of the mechanisms of chemotherapy-induced follicle depletion. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ovarian function and disorders
Share to Renal and related cancers
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30953068
DOI: 10.1093/molehr/gaz020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytesPMID 30953068Read ↗

Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activationSemantic proximity Read ↗

Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian agingSemantic proximity Read ↗

Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles?Semantic proximity Read ↗

<i>In Vivo</i> Mechanisms of Chemotherapy-Induced Acute Follicle Loss in the Human Ovary: An Individual-Oocyte Transcriptomic Analysis from Human Ovarian XenograftsSemantic proximity Read ↗

Novel insights into the pathophysiology of chemotherapy-induced damage to the ovarySemantic proximity Read ↗

DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian ReserveSemantic proximity Read ↗

The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageingSemantic proximity Read ↗

CHEK2 SIGNALING IS THE KEY REGULATOR OF OOCYTE SURVIVAL AFTER CHEMOTHERAPYSemantic proximity Read ↗

Cyclophosphamide chemotherapy induces early p53-directed cytotoxic gene expression changes in ovarian gonadotoxicitySemantic proximity Read ↗

The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cellsSemantic proximity Read ↗

Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transcription During Oocyte GrowthSemantic proximity Read ↗

Acute Doxorubicin Insult in the Mouse Ovary Is Cell- and Follicle-Type DependentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.