Exposure to environmentally relevant concentrations of ambient fine particulate matter (PM2.5) depletes the ovarian follicle reserve and causes sex-dependent cardiovascular changes in apolipoprotein E null mice

Abstract excerpt

Abstract Background Fine particulate matter (PM 2.5 ) exposure accelerates atherosclerosis and contains known ovotoxic chemicals. However, effects of exposure to PM 2.5 on the finite ovarian follicle pool have hardly been investigated, nor have interactions between ovarian and cardiovascular effects. We hypothesized that subchronic inhalation exposure to human-relevant concentrations of PM 2.5 results in...

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