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Article

Induction of proapoptotic gene expression and recruitment of p53 herald ovarian follicle loss caused by polycyclic aromatic hydrocarbons.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Apr 2009

Pru James K, Kaneko-Tarui Tomoko, Jurisicova Andrea, Kashiwagi Aki, Selesniemi Kaisa, Tilly Jonathan L

Abstract excerpt

Activation of the aryl hydrocarbon receptor (AHR) by polycyclic aromatic hydrocarbons (PAH), a ubiquitous class of environmental and occupational biohazards, accelerates germ cell depletion in female mice during prenatal and postnatal life. Like AHR, BAX is also functionally required for PAH to kill oocytes. Here, we show that PAH upregulates ovarian expression of not just Bax but a large cassette of proapoptotic...

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Source

Identifiers

PMID: 19087973
DOI: 10.1177/1933719108327596

Genes

PAH
AHR
BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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