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Article

Structural integration in hypoxia-inducible factors.

Nature - 20 Aug 2015

Wu Dalei, Potluri Nalini, Lu Jingping, Kim Youngchang, Rastinejad Fraydoon

Abstract excerpt

The hypoxia-inducible factors (HIFs) coordinate cellular adaptations to low oxygen stress by regulating transcriptional programs in erythropoiesis, angiogenesis and metabolism. These programs promote the growth and progression of many tumours, making HIFs attractive anticancer targets. Transcriptionally active HIFs consist of HIF-α and ARNT (also called HIF-1β) subunits. Here we describe crystal structures for...

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Source

Identifiers

PMID: 26245371
DOI: 10.1038/nature14883

Genes

ARNT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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