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Article

Structural and functional analysis of amphioxus HIFα reveals ancient features of the HIFα family.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2014

Gao Shan, Lu Ling, Bai Yan, Zhang Peng, Song Weibo, Duan Cunming

Abstract excerpt

Hypoxia-inducible factors (HIFs) are master regulators of the transcriptional response to hypoxia. To gain insight into the structural and functional evolution of the HIF family, we characterized the HIFα gene from amphioxus, an invertebrate chordate, and identified several alternatively spliced HIFα isoforms. Whereas HIFα Ia, the full-length isoform, contained a complete oxygen-dependent degradation (ODD)...

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Identifiers

PMID: 24174425
DOI: 10.1096/fj.12-220152
PMCID: PMC3963020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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