Article
Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor.
The Journal of biological chemistry - 28 Oct 2005
Yang Jinsong, Zhang Lei, Erbel Paul J A, Gardner Kevin H, Ding Kan, Garcia Joseph A, Bruick Richard K
Abstract excerpt
The heterodimeric transcription factor hypoxia-inducible factor (HIF) plays an important role in the progression of a number of processes in which O2 availability is compromised and, as such, has become an increasingly attractive therapeutic target. Although tremendous progress has been made in recent years in unraveling the mechanisms underlying O2-dependent regulation of HIF through its O2-dependent degradation...
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