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Article

Ligand-induced perturbation of the HIF-2α:ARNT dimer dynamics.

PLoS computational biology - 1 Feb 2018

Motta Stefano, Minici Claudia, Corrada Dario, Bonati Laura, Pandini Alessandro

Abstract excerpt

Hypoxia inducible factors (HIFs) are transcription factors belonging to the basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) protein family with a role in sensing oxygen levels in the cell. Under hypoxia, the HIF-α degradation pathway is blocked and dimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT) makes HIF-α transcriptionally active. Due to the common hypoxic environment of tumors,...

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Share to Aryl Hydrocarbon Receptor Nuclear Translocator
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29489822
DOI: 10.1371/journal.pcbi.1006021
PMCID: PMC5847239

Genes

ARNT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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