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Hypoxia-inducible factors: cancer progression and clinical translation

31 May 2022

Abstract excerpt

Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2 supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co-opt this homeostatic system to drive cancer progression. HIFs activate the transcription of thousands of genes that mediate angiogenesis, cancer stem cell specification, cell motility, epithelial-mesenchymal transition,...

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PMID: 35642641
DOI: 10.1172/jci159839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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