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Article

Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor.

Journal of medicinal chemistry - 28 Feb 2013

Rogers Jamie L, Bayeh Liela, Scheuermann Thomas H, Longgood Jamie, Key Jason, Naidoo Jacinth, Melito Lisa, Shokri Cameron, Frantz Doug E, Bruick Richard K, Gardner Kevin H, MacMillan John B, Tambar Uttam K

Abstract excerpt

Hypoxia inducible factors (HIFs) are heterodimeric transcription factors induced in a variety of pathophysiological settings, including cancer. We describe the first detailed structure-activity relationship study of small molecules designed to inhibit HIF-2α-ARNT heterodimerization by binding an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23363003
DOI: 10.1021/jm301847z
PMCID: PMC3676484

Genes

ARNT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23363003-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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