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Article

The Impact of Microenvironmental Heterogeneity on the Evolution of Drug Resistance in Cancer Cells

1 Jan 2015

Abstract excerpt

Therapeutic resistance arises as a result of evolutionary processes driven by dynamic feedback between a heterogeneous cell population and environmental selective pressures. Previous studies have suggested that mutations conferring resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in non-small-cell lung cancer (NSCLC) cells lower the fitness of resistant cells relative to...

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PMID: 26244007
DOI: 10.4137/cin.s19338

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