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Article

Understanding the role of phenotypic switching in cancer drug resistance.

Journal of theoretical biology - 7 Apr 2020

Gunnarsson Einar Bjarki, De Subhajyoti, Leder Kevin, Foo Jasmine

Abstract excerpt

The emergence of acquired drug resistance in cancer represents a major barrier to treatment success. While research has traditionally focused on genetic sources of resistance, recent findings suggest that cancer cells can acquire transient resistant phenotypes via epigenetic modifications and other non-genetic mechanisms. Although these resistant phenotypes are eventually relinquished by individual cells, they...

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Identifiers

PMID: 31953135
DOI: 10.1016/j.jtbi.2020.110162
PMCID: PMC7785289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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