Article

Dissecting targeted therapy resistance: Integrating models to quantify environment mediated drug resistance

2017-07-06

Abstract excerpt

Drug resistance is the single most important driver of cancer treatment failure for modern targeted therapies. This resistance may be due to the presence of dormant or aggressive tumor cell phenotypes or to context-driven protection. Non-malignant cells and other factors, constituting the microenvironment in which the tumor grows (the stroma), are now thought to play a crucial role in both therapeutic response and...

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Literature Corpus work: 276d0b3b-3ae1-595a-83a5-9013beaaed0d
DOI: 10.1101/156547

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