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Article

Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies.

Cancer research - 15 Apr 2018

Gallaher Jill A, Enriquez-Navas Pedro M, Luddy Kimberly A, Gatenby Robert A, Anderson Alexander R A

Abstract excerpt

Treatment of advanced cancers has benefited from new agents that supplement or bypass conventional therapies. However, even effective therapies fail as cancer cells deploy a wide range of resistance strategies. We propose that evolutionary dynamics ultimately determine survival and proliferation of resistant cells. Therefore, evolutionary strategies should be used with conventional therapies to delay or prevent...

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Identifiers

PMID: 29382708
DOI: 10.1158/0008-5472.CAN-17-2649
PMCID: PMC5899666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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