Article

Agent-based models help interpret patterns of clinical drug resistance by contextualizing competition between distinct drug failure modes

2022-02-28

Abstract excerpt

<h4>Structured Abstract</h4> <h4>Introduction</h4> Modern targeted cancer therapies are carefully crafted small molecules. These exquisite technologies exhibit an astonishing diversity of failure modes (drug resistance mechanisms) in the clinic. This diversity is surprising because back of the envelope calculations and classic modeling results in evolutionary dynamics suggest that the diversity in the modes of c...

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Literature Corpus work: ded24aef-c5d9-5a4a-99a1-a5ceb09850ac
DOI: 10.1101/2022.02.25.481999

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