Article

Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution

2016-11-08

Abstract excerpt

1 The success of targeted cancer therapy is limited by drug resistance that can result from tumor genetic heterogeneity. The current approach to address resistance typically involves initiating a new treatment after clinical/radiographic disease progression, ultimately resulting in futility in most patients. Towards a potential alternative solution, we developed a novel computational framework that uses human canc...

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Identifiers and source

Literature Corpus work: 81ed0bb1-2cad-56f8-832d-ffb96f8a4713
DOI: 10.1101/086553

Open publication

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