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Article

The development of drug resistance in metastatic tumours under chemotherapy: An evolutionary perspective.

Journal of theoretical biology - 7 Dec 2024

Padovano Federica, Villa Chiara

Abstract excerpt

We present a mathematical model of the evolutionary dynamics of a metastatic tumour under chemotherapy, comprising non-local partial differential equations for the phenotype-structured cell populations in the primary tumour and its metastasis. These equations are coupled with a physiologically-based pharmacokinetic model of drug administration and distribution, implementing a realistic delivery schedule. The...

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PMID: 39369787
DOI: 10.1016/j.jtbi.2024.111957

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