Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In Silico Assessment of Genetic Variation in PITX2 Reveals the Molecular Mechanisms of Calcium-Mediated Cellular Triggered Activity in Atrial Fibrillation.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference - 1 Jul 2020

Bai Jieyun, Zhu Yijie, Lo Andy, Lu Yaosheng, Zhao Jichao

Abstract excerpt

Genome-wide association studies have identified genetic variants including rs13143308T in the homeobox gene Pitx2 associated with atrial fibrillation (AF) populations. However, the molecular mechanisms leading to AF due to the rs13143308T variant are poorly understood. Therefore, this study aims to investigate the effects of this variant-induced alteration in calcium handling on properties of Ca2+-transients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrial Fibrillation
Share to Calcium

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Homeobox Protein PITX2

Share to Homeodomain Proteins

Share to Ryanodine Receptor Calcium Release Channel

Share to Transcription Factors

Source

Identifiers

PMID: 33018479
DOI: 10.1109/EMBC44109.2020.9175466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In Silico Assessment of Genetic Variation in PITX2 Reveals the Molecular Mechanisms of Calcium-Mediated Cellular Triggered Activity in Atrial Fibrillation.PMID 33018479Read ↗

In silico investigation of the mechanisms underlying atrial fibrillation due to impaired Pitx2.Semantic proximity Read ↗

Understanding PITX2-dependent Atrial Fibrillation Mechanisms through Computational ModelsSemantic proximity Read ↗

Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models.Semantic proximity Read ↗

Pitx2 impairs calcium handling in a dose-dependent manner by modulating Wnt signallingSemantic proximity Read ↗

The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis.Semantic proximity Read ↗

Multiple 4q25 risk variants impair calcium homeostasis and compromise left atrial function.Semantic proximity Read ↗

Modulation of conductive elements by Pitx2 and their impact on atrial arrhythmogenesis.Semantic proximity Read ↗

PITX2-dependent gene regulation in atrial fibrillation and rhythm control.Semantic proximity Read ↗

PITX2C Deficiency Promotes Arrhythmogenic Remodeling via Oxidative Stress in Atrial MyocytesSemantic proximity Read ↗

Novel RyR2 Mutation (G3118R) Is Associated With Autosomal Recessive Ventricular Fibrillation and Sudden Death: Clinical, Functional, and Computational Analysis.Semantic proximity Read ↗

A gain of function mutation in PITX2c gene linked to atrial fibrillation alters mitochondrial function and membrane excitability.Semantic proximity Read ↗

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.