Article
Differential Expression of Hypertensive Phenotypes in BXD Mouse Strains in Response to Angiotensin II.
American journal of hypertension - 8 Dec 2017
Zhao Wenyuan, Zhao Tieqiang, Chen Yuanjian, Bhattacharya Syamal K, Lu Lu, Sun Yao
Abstract excerpt
BACKGROUND: Besides environmental risk factors, genetic factors play a crucial role in the pathogenesis of primary hypertension. The current study is to unravel whether hypertensive phenotypes vary in mice with different genetic background. METHODS: Hypertension was induced in C57BL/6J (B6), DBA/2J (D2), and 25 BXD strains by administrating angiotensin (Ang)II (2.5 mg/kg/day infused by osmotic minipump) for 4...
Topics
- Angiotensin II
- Animals
- Blood Pressure
- Fibrosis
- Heart Diseases
- Hypertension
- Inflammation
- Kidney Diseases
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Inbred Strains
- Phenotype
- Species Specificity
- Transforming Growth Factor beta
- Vasoconstrictor Agents