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Article

Identifying modifier genes for hypertrophic cardiomyopathy.

Journal of molecular and cellular cardiology - 1 Jul 2020

Chen Yuanjian, Xu Fuyi, Munkhsaikhan Undral, Boyle Charlie, Borcky Theresa, Zhao Wenyuan, Purevjav Enkhsaikhan, Towbin Jeffrey A, Liao Fang, Williams Robert W, Bhattacharya Syamal K, Lu Lu, Sun Yao

Abstract excerpt

BACKGROUND: Hypertrophic cardiomyopathy (HCM) severity greatly varies among patients even with the same HCM gene mutations. This variation is largely regulated by modifier gene(s), which, however, remain largely unknown. The current study is aimed to identify modifier genes using BXD strains, a large murine genetic reference population (GRP) derived from crosses between C57BL/6 J (B6) and D2 DBA/2 J (D2) mice. D2...

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Share to Cardiomyopathy, Hypertrophic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Genetic

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Share to Myocytes, Cardiac

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Source

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Identifiers

PMID: 32470469
DOI: 10.1016/j.yjmcc.2020.05.006
PMCID: PMC9768851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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