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Article

Echocardiography phenotyping in murine genetic reference population of BXD strains reveals significant QTLs associated with cardiac function and morphology.

Physiological genomics - 1 Feb 2023

Orgil Buyan-Ochir, Xu Fuyi, Munkhsaikhan Undral, Alberson Neely R, Bajpai Akhilesh Kumar, Johnson Jason N, Sun Yao, Towbin Jeffrey A, Lu Lu, Purevjav Enkhsaikhan

Abstract excerpt

The genetic reference population of recombinant inbred BXD mice has been derived from crosses between C57BL/6J and DBA/2J strains. The DBA/2J parent exhibits cardiomyopathy phenotypes, whereas C57BL/6J has normal heart. BXD mice are sequenced for studying genetic interactions in cardiomyopathies. The study aimed to assess cardiomyopathy traits in BXDs and investigate the quantitative genetic architecture of those...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36534598
DOI: 10.1152/physiolgenomics.00120.2022
PMCID: PMC9902221

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