Article
A population-based case-control study of genetic variation in cytokine genes associated with risk of cervical and vulvar cancers.
Gynecologic oncology - 1 Oct 2015
Hardikar Sheetal, Johnson Lisa G, Malkki Mari, Petersdorf Effie W, Galloway Denise A, Schwartz Stephen M, Madeleine Margaret M
Abstract excerpt
OBJECTIVE: Persistent infection with oncogenic human papillomavirus (HPV) is known to be the necessary cause of cervical cancer and a majority of vulvar cancers. Persistent HPV infections must evade host immune responses, including cytokines released by activated T-helper (Th) cells. In this study, we investigated the risk of cervical and vulvar cancers associated with common genetic variations in 560 tagging...
Topics
- Adult
- Carcinoma, Squamous Cell
- Case-Control Studies
- Cytokines
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Middle Aged
- Papillomavirus Infections