Article
Tumor necrosis factor (TNF) alpha and interleukin (IL) 18 genes polymorphisms are correlated with susceptibility to HPV infection in patients with and without cervical intraepithelial lesion.
Annals of human biology - 1 May 2016
Tavares Mayara C Mansur, de Lima Júnior Sérgio F, Coelho Antonio V C, Marques Trícia Ruschelle N M, de Araújo Diêgo Henrique T, Heráclio Sandra de A, Amorim Melânia M Ramos, de Souza Paulo Roberto E, Crovella Sergio
Abstract excerpt
BACKGROUND: The Human Papillomavirus (HPV) predisposes 500 000 women to cervical cancer. Host genetic background may facilitate virus persistence in the uterine cervix. Polymorphisms in regulatory and coding regions of cytokine genes have been associated with susceptibility to some human diseases. AIM: This study aims at investigating whether TNFA -308 G/A and IL18 -137 G/C and -607 C/A polymorphisms are...
Topics
- Adolescent
- Adult
- Aged
- Female
- Genetic Predisposition to Disease
- Humans
- Interleukin-18
- Middle Aged
- Papillomaviridae
- Papillomavirus Infections
- Polymorphism, Single Nucleotide
- Tumor Necrosis Factor-alpha