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Role of human papillomavirus (HPV) variants and host genetic susceptibility in cervical carcinogenesis.

Archives of microbiology - 16 Feb 2026

Singh Ankita, Sahani Priya, Singh Shivangi, Ojha Anupama, Gupta Poonam, Awasthi Chakra Pani, Birbiya Narendra, Mishra Sarad Kumar

Abstract excerpt

Cervical carcinoma continues to be one of the leading causes of cancer-related mortality among women worldwide, disproportionately striking developing regions, including India. High-risk persistent HPV infection has long been recognized as the central etiological factor in cervical carcinogenesis; however, not all infected women end up with malignancy, indicating the role of viral genomic variation and host...

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PMID: 41697429
DOI: 10.1007/s00203-026-04722-y

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GSTM1
GSTT1
MTHFR
TNF
TP53
XRCC1

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