Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in immune mediators associate with risk of cervical cancer.

Gynecologic oncology - 1 Oct 2014

Zhang Zhengyan, Fye Samantha, Borecki Ingrid B, Rader Janet S

Abstract excerpt

OBJECTIVE: The immune system is critical for controlling the progression of HPV cervical disease and the development of cancer. This study aimed to identify cervical cancer susceptibility alleles in candidate immune-modulating genes. METHODS: Our family-based study involved a cohort of 641 probands (women with ICC/CIN III) and their biologic parents or siblings (641 trios). In the discovery phase (stage 1),...

Topics

Adult
Female
Genetic Association Studies
Humans
Immunologic Factors
Polymorphism, Single Nucleotide
Risk Factors
Uterine Cervical Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25127987
DOI: 10.1016/j.ygyno.2014.07.106
PMCID: PMC4198466

Genes

JAK2
STAT6
IFNG
IFNGR1
IFNGR2
JAK1
LTA
LTB
STAT1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in immune mediators associate with risk of cervical cancer.PMID 25127987Read ↗

Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review.Semantic proximity Read ↗

A population-based case-control study of genetic variation in cytokine genes associated with risk of cervical and vulvar cancers.Semantic proximity Read ↗

Genome‐Wide Association Analyses of HPV16 and HPV18 Seropositivity Identify Susceptibility Loci for Cervical CancerSemantic proximity Read ↗

Genomic Risk Factors for Cervical CancerSemantic proximity Read ↗

Immunogenomic Identification for Predicting the Prognosis of Cervical Cancer PatientsSemantic proximity Read ↗

Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine cluster.Semantic proximity Read ↗

Risk allelic load in Th2 and Th3 cytokines genes as biomarker of susceptibility to HPV-16 positive cervical cancer: a case control study.Semantic proximity Read ↗

Prioritization and Meta-analysis of regulatory SNPs identified IL6, TGFB1, TLR9 and MMP7 as significantly associated with cervical cancer.Semantic proximity Read ↗

Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women.Semantic proximity Read ↗

Genetic Variants of Interleukin-8 and Interleukin-16 and Their Association with Cervical Cancer RiskSemantic proximity Read ↗

Interaction of immunological genes on chromosome 2q33 and IFNG in susceptibility to cervical cancer.Semantic proximity Read ↗

Immune Cells and Risk of Cervical Cancer: Evidence from a Mendelian Randomization Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.