Article
Risk allelic load in Th2 and Th3 cytokines genes as biomarker of susceptibility to HPV-16 positive cervical cancer: a case control study.
BMC cancer - 24 May 2016
Torres-Poveda K, Burguete-García A I, Bahena-Román M, Méndez-Martínez R, Zurita-Díaz M A, López-Estrada G, Delgado-Romero K, Peralta-Zaragoza O, Bermúdez-Morales V H, Cantú D, García-Carrancá A, Madrid-Marina V
Abstract excerpt
BACKGROUND: Alterations in the host cellular immune response allow persistent infections with High-Risk Human Papillomavirus (HR-HPV) and development of premalignant cervical lesions and cervical cancer (CC). Variations of immunosuppressive cytokine levels in cervix are associated with the natural history of CC. To assess the potential role of genetic host immunity and cytokines serum levels in the risk of...
Topics
- Adult
- Alleles
- Biomarkers
- Biomarkers, Tumor
- Carcinoma, Squamous Cell
- Case-Control Studies
- Cytokines
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease