Article
Nucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: a hybrid case-parent triad and case-control study.
International journal of cancer - 1 Jul 2013
Hussain Shehnaz K, Madeleine Margaret M, Johnson Lisa G, Du Qin, Galloway Denise A, Daling Janet R, Malkki Mari, Petersdorf Effie W, Schwartz Stephen M
Abstract excerpt
Given the important role of cell mediated immunity in viral clearance and control of premalignant lesions, we hypothesize that variation in the IL-12/IL-10 cytokine and cytokine receptor genes may influence cervical and vulvar cancer risk. We evaluated 76 tagSNPs from seven candidate genes (IL-10, IL-12A, IL-12B, IL-10RA, IL-10RB, IL-12RB1, and IL12RB2) in case-parent sets (n=43 cervical squamous cell carcinoma...
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